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Clinical trials
- Participate in a clinical trial
- For medical professionals
- Active clinical trials for pediatric cancers
- CAR-20/19-T cells in pediatric and young adult patients with relapsed/refractory B Cell Acute Lymphoblastic Leukemia (CAR-20/19-T) phase 1 clinical trial
- Unrelated and partially matched related donor peripheral stem cell transplantation for patients with hematologic malignancies clinical trial
- Early stage research
Active clinical trials
Cancer Clinical Trials - MAGIC-LRPEDS
Protocol Summary
- Protocol No
- MAGIC-LRPEDS
- Principal Investigator
- Julie-An Talano
- Phase
- II
- Title
- Serial Response and Biomarker-Guided Steroid Taper for Children with GVHD
- Associated Disease(s)
-
Acute Lymphoblastic Leukemia (ALL)
Acute Myelogenous Leukemia (AML)
Other Leukemia
- Description (Summary)
- We're doing this study to find out how many subjects respond well to lower steroid dosing and if they develop fewer complications. This will be assessed by both the clinical response and a blood test (GVHD biomarkers) developed by the researchers of this study. They found that pediatric patients who have low GVHD biomarkers at the start of treatment and for the first two weeks of treatment have a very high response rate to steroids (96%) that lasts. In this study, we will decrease the amount of steroids used to treat GVHD patients who are expected to respond very well. We will do this by starting at a lower dose of prednisone and reducing the dose rapidly to see if the biomarkers stay low and the subject is responding. If the GVHD symptoms get worse or if the biomarkers increase, which may occur in some subjects we will increase the steroid dose.
We also want to study how the treatments affect your quality of life. We will use surveys to obtain the patient's own assessment of their quality of life (down to age 8) and a parental proxy survey for patients ages 5 to 17. Quality of life means how well you can do your normal everyday activities. We hope that the results of this research will help us develop treatments for GVHD that are safer than currently available.
- Participating Institutions
- Childrens Hospital of Wisconsin
- ClinicalTrials.gov
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